Medical Marijuana is very popular among patients with AIDS, with one of the main reasons being that it is able to soothe a variety of the disease symptoms. It can soothe pain, stimulate appetite, and calm nausea.

HIV attacks the immune system. It can result in painful nerve damage, anxiety, depression, vomiting, nausea, and significant weight loss.

Recent multiple medical treatment has gotten to the point where people with AIDS live a lot longer it’s more of a chronic one than one that is quickly fatal. This is thanks to the advances of modern medicine. These medications have 2 effects: One is that they allow hope to individuals, the 2nd is they cause sick side effects. Fatigue, nausea, diarrhea, and appetite loss can happen all the time and need to be tolerated. Or do they?

Antiviral medications nicely control in most cases HIV progression. They unfortunately produce vomiting and nausea which is quite similar to cancer chemo patients.

Loss of lean body mass may result in AIDS patients from cachexia as a result of nausea and appetite loss. The FDA n 1986 approved Marinol, called dronabinol, for weight loss from AIDS. For people suffering from HIV, losing as little as five percent of their lean body mass may be life risking.

When someone loses more than 10% of their body weight involuntarily, the CDC calls it AIDS wasting syndrome. Also this includes diarrhea and fever persisting for over 30 days. In addition to lean muscle tissue, they may lose tissue from internal organs like the liver.

Traditional treatments for wasting include the medications Megace and Marinol (prescribed less often). People on Megace typically are able to increase food intake by 30%, but tend to gain fat over lean tissue mass. THC in the form of Marinol has been shown to increase appetite and maintain weight with slight side effects of dry mouth and slight psychological distress.

Mostly with these reasons, patients with AIDS report better results with smoking marijuana. When smoking, AIDS patients may smoke in just enough to help with symptoms. The help is typically substantial, and appetite stimulation is rapid.

Intake of marijuana has a definite place in treating weight loss and AIDS wasting. This place actually works potentially in conjunction with growth hormone or testosterone to maintain and/or restore lean body tissue.

In addition to helping AIDS individuals take in more food, marijuana may assist with pain. AIDS may cause neuropathic pain, which is a burning type of pain. Marijuana works well for this neuropathic pain.

Along with this, AIDS patients report substantial mood improvement. Giving a psychological lift to AIDS patients, which represents a devastating disease, a psychological lift in addition to the other symptom improvements gives marijuana a definite advantage when compared with solo medications.

Marijuana has a definite treatment place for AIDs patients. By releiving nausea, appetite loss, anxiety, and pain it helps with multiple side effects. Smoking or vaporizing has been shown in small research studies to have a quicker onset and easier dosing than oral medications.

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The FDA approved Marinol as a synthetic medical marijuana THC medication. It has an indication in oral form for combating nausea with chemotherapy and in addition for appetite stimulation with AIDS patients. There is considerable debate between whether to use natural smoke marijuana versus oral Marinol for these diseases. The article’s purpose is to give an overview of how the FDA approves a medication like Marinol.

In the US, the Food and Drug Administration decides if a drug is safe for human consumption in the marketplace. How does it get there? A clinical trial is conducted and is typically sponsored by the drug sponsor.

The vast majority of the time, the sponsor is a drug manufacturer. Some people look down on the manufacturers because of the amount of money they make, but it costs a fortune to pay for modern clinical studies. A significant amount of medication breakthroughs come out of these trials, including chemo breakthroughs which extend life and also less substantial breakthroughs like Viagra.

Commercial development of medications also occurs through NIH grants for severe diseases like AIDS, epilepsy, MS, ALS, and Cancer. The NIH assisted in the commercial development of Marinol with one of these programs

Before a drug ends up in human testing, it is often tested in animals. Animal rights groups do not like this one bit, but it is reality. If you had a loved one dying of cancer, you might think differently about a life extending medication that had its origin being studied in mice originally. When animals are studied, this is the preclinical drug phase.

Let’s consider a research doctor is looking at appetite in mice. This may include a disease in mice that reduces appetite. In the research the mice are either given the Gold Standard drug at the time or the investigational drug. The the investigational drug works, the company turns in and Investigational New Drug application to the Food and Drug Administration. The FDA can contest the application within 30 days, and if not the drug company can start human testing

Usually 3 clinical trials occur. Phase 1 entails giving the drug to healthy volunteers who do not have the disease to determine safety. Phase two involves a small number of patients being treated who have the condition under investigation. Side effects and safety profile is established. Phase 3 looks at a large number of patients to gain statistical significance on effectiveness.

How long does all this take? On average, an unbelievable 5 years. If it is a complicated experimental drug, it may take longer. Also, if the condition is rare, it may take a while to enroll enough patients.

How many drugs make it through? About one in five drugs that start the process secure FDA approval. Considering the cost of all 3 phases runs anywhere from $200 million to $600 million, these trials are very risky.

After Phase 3, a New Drug Application is submitted to the FDA for marketing approval. It then takes an average of 1.25 years for the FDA to complete its review. Since 1992 when the FDA was allowed to charge fees it has allowed more staffing and the time for review has dropped from 2 years to 15 months.

At that point the FDA approves the drug for a specific indication. If the pharmaceutical company wants another indication, a supplemental application process is necessary. Marinol represents the only prescription medication in the US which is a synthetic medical marijuana. In just 2 years, Marinol shifted from Investigation New Drug to approval.

That initial approval was for nausea and vomiting associated with cancer chemotherapy in 1985. In 1992, the drug maker applied and received FDA approval for AIDS wasting

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